Inotropic and toxic effects of a polar cardiac glycoside derivative in the dog.

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Inotropic and toxic effects of a polar cardiac glycoside derivative in the dog.

It has been suggested that central nervous system (CNS) neuroexcitation plays an important role in digitalis-induced cardiac arrhythmias. To elucidate further the role of the CNS in digitalis-induced arrhythmias, the inotropic and toxic effects of a highly polar semisynthetic cardiac glycoside, 3beta-O-(4 amino-4,6 dideoxy-beta-D-galactopyranosyl)-digitoxigenin (ASI-222) were compared to those ...

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On the polar derivative of a polynomial

For a polynomial p(z) of degree n, having all zeros in |z|< k, k< 1, Dewan et al [K. K. Dewan, N. Singh and A. Mir, Extension of some polynomial inequalities to the polar derivative, J. Math. Anal. Appl. 352 (2009) 807-815] obtained inequality between the polar derivative of p(z) and maximum modulus of p(z). In this paper we improve and extend the above inequality. Our result generalizes certai...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1978

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.43.6.847